Publications

Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer
Bar-Peled L, Kemper EK, Suciu RM, Vinogradova EV, Backus KM, Horning BD, Paul TA, Ichu TA, Svensson RU, Olucha J, Chang MW, Kok BP, Zhu Z, Ihle NT, Dix MM, Jiang P, Hayward MM, Saez E, Shaw RJ, Cravatt BF.
Cell. 2017 Sep 27. pii: S0092-8674(17)31047-4. doi: 10.1016/j.cell.2017.08.051. [Epub ahead of print]

Global profiling of lysine reactivity and ligandability in the human proteome
Stephan M. Hacker, Keriann M. Backus, Michael R. Lazear, Stefano Forli, Bruno E. Correia & Benjamin F. Cravatt
Nature Chemistry, doi:10.1038/nchem.2826, 2017

Ligand and Target Discovery by Fragment-Based Screening in Human Cells
Parker CG, Galmozzi A, Wang Y, Correia BE, Sasaki K, Joslyn CM, Kim AS, Cavallaro CL, Lawrence RM, Johnson SR, Narvaiza I, Saez E, Cravatt BF.
Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.

Proteome-wide covalent ligand discovery in native biological systems
Backus KM, Correia BE, Lum KM, Forli S, Horning BD, González-Páez GE, Chatterjee S, Lanning BR, Teijaro JR, Olson AJ, Wolan DW, Cravatt BF.
Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.

Chemical proteomic map of dimethyl fumarate-sensitive cysteines in primary human T cells
Blewett MM, Xie J, Zaro BW, Backus KM, Altman A, Teijaro JR, Cravatt BF.
Sci Signal. 2016 Sep 13;9(445):rs10. doi: 10.1126/scisignal.aaf7694.

A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells
Niphakis MJ, Lum KM, Cognetta AB 3rd, Correia BE, Ichu TA, Olucha J, Brown SJ, Kundu S, Piscitelli F, Rosen H, Cravatt BF.
Cell. 2015 Jun 18;161(7):1668-80. doi: 10.1016/j.cell.2015.05.045.

Quantitative reactivity profiling predicts functional cysteines in proteomes
Weerapana E, Wang C, Simon GM, Richter F, Khare S, Dillon MB, Bachovchin DA, Mowen K, Baker D, Cravatt BF.
Nature. 2010 Dec 9;468(7325):790-5. doi: 10.1038/nature09472. Epub 2010 Nov 17.