Expanding the Reach of Small Molecule Therapeutics

Latest News

Vividion Therapeutics Announces Oversubscribed $82 Million
Series B Financing

About

Vividion Therapeutics is expanding the therapeutic potential of small molecules to create transformative medicines. Our cutting-edge platform combines proteomics and pioneering chemistry to reveal druggable opportunities across the entire proteome, much of it previously considered undruggable. We are advancing a pipeline of programs across a range of unmet medical needs.

A Paradigm Shift In Small Molecule Discovery

    Vividion combines a proteome-wide small molecule screening approach and cutting-edge synthetic chemistry techniques pioneered by our scientific founders. We have created the world’s premier covalent small molecule fragment library, which we deploy on a proteome-wide scale to uncover an unprecedented breadth of leads for drug discovery.

Unlocking Previously Intractable Drug Targets

    By screening against every protein in a cell simultaneously, in native biological systems, we eliminate the artifacts and limitations of traditional screening methods. Our platform provides an unprecedented view of small molecule selectivity and creates a path to drugging any protein, agnostic to class.

A Broad Palette of Therapeutic Opportunities

    Vividion’s approach uncovers previously undiscovered druggable pockets on proteins, thus unlocking the full universe of targets accessible to small molecules. This opens up a range of therapeutic strategies, from direct inhibition to allosteric modulation to targeted degradation.

Platform

Vividion’s platform uncovers novel pockets on proteins, identifying small molecule ligands to these targets that can then be exploited with a variety of therapeutic strategies (e.g., direct inhibition, allosteric modulation, targeted degradation).

We are advancing several therapeutic candidates that are highly selective for proteins with critical roles in disease pathways and have the potential to be transformative across a broad range of unmet medical needs.

Publications

Team

Benjamin F. Cravatt

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Benjamin F. Cravatt is a Professor and Co-Chair of the Department of Molecular Medicine at The Scripps Research Institute. His research group is interested in understanding the roles that enzymes play in physiological and pathological processes, especially as pertains to the nervous system and cancer.  Dr. Cravatt obtained his undergraduate education at Stanford University, receiving a B.S. in the Biological Sciences and a B.A. in History.  He then received a Ph.D. from The Scripps Research Institute (TSRI) in 1996. Professor Cravatt joined the faculty at TSRI in 1997. Dr. Cravatt is a co-founder and scientific advisor of Activx Biosciences, Abide Therapeutics, and Vividion Therapeutics. His honors include a Searle Scholar Award, the Eli Lilly Award in Biological Chemistry, a Cope Scholar Award, the Protein Society Irving Sigal Young Investigator Award, the Tetrahedron Young Investigator Award in Bioorganic and Medicinal Chemistry, the ASBMB Merck Award, and memberships in the National Academy of Sciences and American Academy of Arts and Sciences.

Phil S. Baran

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Phil Baran received his B.S. in chemistry from NYU in 1997, his Ph.D. at The Scripps Research Institute in 2001, and from 2001-2003 he was an NIH-postdoctoral fellow at Harvard. Dr. Baran began his independent career at Scripps in the summer of 2003. He currently holds the Darlene Shiley Chair in Chemistry. He has published over 180 scientific articles and has been the recipient of several ACS awards such as the Corey (2015), Pure Chemistry (2010), Fresenius (2006), and Nobel Laureate Signature (2003), and several international distinctions such as the Hirata Gold Medal and Mukaiyama Prize (Japan), the RSC award in Synthesis (UK), and the Sackler Prize (Israel). In 2013 he was named a MacArthur Foundation Fellow, in 2015 he was elected to the American Academy of Arts and Sciences, and in 2016 he was awarded the Blavatnik National Award.

Dr. Baran has delivered hundreds of lectures around the world and consults for numerous companies such as Bristol-Myers Squibb (since late 2005), Boehringer-Ingelheim, AstraZeneca, DuPont and TEVA, and is a scientific advisory board member for Eisai, Abide, and AsymChem. In 2016 he was appointed as an Associate Editor for the Journal of the American Chemical Society. He co-founded Sirenas Marine Discovery (2012) and Vividion Therapeutics (2016) and in 2013 he co-authored The Portable Chemist’s Consultant, an interactive book published on the iBooks store along with his graduate class in Heterocyclic Chemistry (viewable for free by anyone on iTunes University). Outside of the lab, Phil enjoys spending time with his wife Ana and three young children (Lucia, Leah, and Manuel).

Jin-Quan Yu

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Jin-Quan Yu received his B.S. in Chemistry at East China Normal University, where he worked with Professor Li-Xin Dai and Professor Bi-Qi Wu as a visiting student at Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences in 1987. Following a one-year course study in Shanghai Institute of Organic Chemistry, Dr. Yu went to Guangzhou Institute of Chemistry, Chinese Academy of Sciences to study terpene chemistry and heterogeneous catalysis under the supervision of Professor Shu-De Xiao and obtained his Master’s degree in 1990. He stayed on as a research associate for four years and went to Cambridge University for his doctoral studies under the supervision of Dr J. B. Spencer, where he studied biosynthesis and the mechanistic details of the hydrometallation step in asymmetric hydrogenation. Dr. Yu was elected as a Junior Research Fellow of St John’s College, Cambridge University in 1998. From 2001-2002, Jin-Quan worked on Pd-catalyzed allylic oxidation as a postdoctoral fellow at the Harvard University in the laboratories of Professor E. J. Corey. He returned to Cambridge University in 2002 and was appointed as a University Royal Society Research Fellow in 2003 to start his independent research towards developing asymmetric C–H insertion reactions. In 2004, he moved to Brandeis University as an Assistant Professor of Chemistry. He joined The Scripps Research Institute as an Associate Professor in 2007 and became a full Professor in August 2010. He was appointed as the Frank and Bertha Hupp Professor of Chemistry at The Scripps Research Institute in 2012. He received Mukaiyama Award in 2012, the Raymond and Beverly Sackler Prize in the Physical Sciences in 2013, the Elias J. Corey Award in 2014, and the MacArthur Fellowship in 2016.

Fred Aslan

President and Chief Business Officer
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Fred joined the Vividion team in September 2018 as President and Chief Business Officer. He was the founder and CEO of Adavium Medical, which he built into the leading Brazilian medical device company, raising over US$50 million from institutional investors.

Prior to Adavium Medical, Fred was a full-time investor at Venrock, a leading venture capital firm he joined in 2006, where he was involved with several successful biotech and medical device companies. He was a co-founder and board member of Receptos Pharmaceuticals, a NASDAQ-listed biotech company, which was subsequently acquired by Celgene for more than $7 billion. Fred also led Venrock’s investment in Zeltiq, a NASDAQ-listed medical device company that was acquired by Allergan for more than $2 billion. Prior to Venrock, he was Director of Business Development and led Investor Relations at CuraGen, a NASDAQ-listed oncology-focused biotech company, and was a strategy consultant with Boston Consulting Group (BCG).
Fred received a B.S. in Biology from Duke University, an M.D. from Yale and an M.B.A. from Harvard.

Larry Burgess

Head of Chemistry
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Larry joined Vividion in September 2018 as Head of Chemistry, bringing extensive scientific leadership and drug development experience to the company. Larry previously served as Vice President of Medicinal Chemistry for Array BioPharma, where he helped to advance many discovery programs that resulted in Investigational New Drug (IND) applications. The majority of those drugs are currently being tested in patients or are approved.
Prior to joining Array BioPharma, Larry was at Amgen and Pfizer. He received a B.S. in chemistry from the Georgia Institute of Technology, a Ph.D. from the University of Texas and completed his postdoctoral research at Colorado State University.

Todd Kinsella

Head of Biology
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Todd Kinsella joined Vividion in 2017 as Vice President of Translational and Development Sciences. Todd supports all stages of Vividion’s therapeutic pipeline from target identification, validation, drug discovery and the translational biology interface connecting pre-clinical programs and development.

Prior to joining Vividion, Todd served as Vice President of Research at Rigel Pharmaceuticals with over 18 years of experience in small molecule and antibody-based drug discovery. He was instrumental in establishing Rigel’s original flagship technology for discovering novel drugable targets. He has founded and served as head of numerous departments within Rigel, and led key drug discovery programs within target discovery-immunology, virology, muscle, metabolism, vascular biology and immuno-oncology.

Todd received his BS in Molecular and Cellular Biology from the University of Arizona and PhD in Molecular Pharmacology from Stanford University. He is an author of 15 published articles and an inventor on 26 issued patents.

Jean Bemis

Head of Alliance Management
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Jean Bemis is Head of Alliance Management at Vividion and has more than 25 years of experience in drug development, from early discovery through IND acceptance and clinical study initiation. Jean was previously involved in new company formation at Gene Sciences, Inc., Rodin Therapeutics and Warp Drive Bio, leading program management and drug development. Prior to that, Jean was an early employee of Catabasis Pharmaceuticals, leading the chemistry group from preclinical discovery to CMC campaigns to support clinical studies. In addition to biotherapeutic start-ups, Jean’s experience also
includes driving programs forward at Amgen, GSK and Wyeth.

Matt Patricelli

Head of Early Discovery
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Matt Patricelli joined Vividion in 2016 as a founding scientific member of the company’s management team.  In his current role, Matt supports all early drug discovery efforts including target selection and validation, as well as the continued development and execution of Vividion’s chemical proteomics platform.

Prior to joining Vividion, Matt served as the Senior Director of Biology at Wellspring Biosciences where he led several drug discovery programs including the KRAS-G12C covalent inhibitor discovery project.  From 2000-2012 Matt led the chemical proteomics platform activities at ActivX Biosciences. He was the first Scientist to join ActivX and played a key role in the development of ActivX’s platform technologies, including establishing the KiNativ platform which continues to operate as a successful commercial screening service.

Matt obtained his BSc in Biochemistry from McGill University, and PhD from The Scripps Research Institute as the first graduate student of Vividion founder Dr. Benjamin Cravatt.  He is an author or co-author of more than 30 scientific publications, and 3 issued patents.

Dean Stamos

Head of Chemistry Innovation
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Dr. Dean Stamos joined Vividion Therapeutics in 2017 as Vice President of Chemistry. In his current role, Dean oversees the strategic growth and implementation of Vividion’s cutting edge chemical proteomics platform to support all aspects of the drug discovery process. Central towards this goal is the full utilization of modern synthetic methodologies coupled with chemical biology insights to deliver high-quality small molecule therapeutics.

Dean joined Vividion with 20 years of leadership experience at Vertex Pharmaceuticals working in multiple therapeutic areas including infectious disease, oncology, inflammation, pain, and neurodegeneration delivering multiple pre-clinical and clinical stage assets. In addition, Dean lead various functions integral to drug discovery including hit to lead, analytical, scale up, and library synthesis as well as the creation of an integrated chemical biology group. As a passionate supporter of exploring novelty and change at the interfaces of chemistry, biology, and leadership, Dean initiated and chaired several internal and external collaborations in the areas of ligand-receptor kinetics, C-H activation, natural products research, and change management.

Dean received his BS in Chemistry from Indiana University, and a PhD in Organic Chemistry from Harvard University. He is an author of 26 published articles and an inventor on 21 patents.

Diego Miralles

CEO
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Diego comes from an extensive background in leading and developing innovative businesses. He was previously President of Adaptive Therapeutics, where he built a therapeutics program leveraging Adaptive immunosequencing platform. He had an extensive career at Johnson & Johnson, which he joined in 2005 as VP of Clinical Development at Tibotec in Belgium where he was involved in the development and approval of PREZISTA® and INTELENCE®, among several other drugs in the portfolio. In 2008, he moved back to the US to head the Janssen Research and Early Development unit in La Jolla, CA.

While at Johnson & Johnson, he founded and launched the JLABS incubator in 2012 for start-up life science entrepreneurs, a model that has been replicated in six locations across North America, and was instrumental in developing and launching Johnson & Johnson’s Innovation center model in 2013. Additionally, he established Janssen Healthcare Innovation in 2011. Through his external networking activities, he contributed significantly to Johnson & Johnson’s growing reputation as an innovative healthcare company.

Prior to Johnson & Johnson, Diego held R&D positions at Trimeris and Triangle Pharmaceuticals and was an Assistant Professor at Duke University Medical Center, where he was a bench scientist and an Infectious Disease physician, with a focus on HIV. He is currently an Adjunct Professor in the Department of Pharmacology at the University of California San Diego. He received his MD degree from the Universidad de Buenos Aires, Argentina. He completed his internal medicine residency at the Mayo Clinic and was a fellow in Infectious Diseases at Cornell University-New York Hospital.

Diego has a strong passion for advancing healthcare innovation on behalf of patients.

Kristina Burow

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Kristina Burow is a Managing Director with ARCH Venture Partners. Ms. Burow is a director of Vividion, Lycera, BlackThorn Therapeutics, Sienna Biopharmaceuticals, Metacrine, Scholar Rock, Unity Biotechnology, AgBiome and Vir Biotechnology, and was a co-founder and director of Receptos (RCPT – acquired by Celgene). She participated in other ARCH portfolio companies including Siluria Technologies, Kythera (KYTH – acquired by Allergan), Ikaria (acquired by Madison Dearborn) and Sapphire Energy (co-founder). Prior to joining ARCH in 2002, Ms. Burow was an Associate with the Novartis BioVenture Fund and was active in Chemistry Operations and Business Development at the Genomics Institute of the Novartis Research Foundation. Ms. Burow holds a M.B.A. from the University of Chicago, a M.A. in Chemistry from Columbia University and a B.S. in Chemistry from the University of California, Berkeley.

John K. Clarke

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John K. Clarke has a 30 year record of early-stage venture capital investment success. John co-founded Cardinal Partners in 1997 and currently serves as a Managing Partner of the firm. John leads Cardinal’s life sciences investment efforts and has had an extraordinary record of success.

Mr. Clarke led the firm’s investment in Cubist Pharmaceuticals, Momenta Pharmaceuticals, Alnylam Pharmaceuticals, and Sirtris Pharmaceuticals. He also spearheaded Cardinal’s investment in and served as a director for: TechRx Corporation and Visicu. Mr. Clarke currently serves on the Board of Directors for Cardinal portfolio companies Abide Therapeutics, aTyr Pharma, Rib-X Pharmaceuticals (observer) and Verastem, as well as Alnylam Pharmaceuticals and Momenta Pharmaceuticals.John entered the venture industry in 1982 with DSV Partners, a pioneer venture capital fund formed in 1968. Additionally, he led DSV’s health care and life sciences efforts, and was a co-founder and served as interim CEO of numerous successful companies including Alkermes, Arris Pharmaceuticals, DNX and Cubist Pharmaceuticals. As managing partner at DSV in that firm’s latter years, Mr. Clarke led the firm’s evolution into Cardinal Partners.

Mr. Clarke received his B.A. in Economics and Biology from Harvard University and his M.B.A. from the Wharton School at the University of Pennsylvania.

Benjamin F. Cravatt

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Benjamin F. Cravatt is a Professor and Co-Chair of the Department of Molecular Medicine at The Scripps Research Institute. His research group is interested in understanding the roles that enzymes play in physiological and pathological processes, especially as pertains to the nervous system and cancer.  Dr. Cravatt obtained his undergraduate education at Stanford University, receiving a B.S. in the Biological Sciences and a B.A. in History.  He then received a Ph.D. from The Scripps Research Institute (TSRI) in 1996. Professor Cravatt joined the faculty at TSRI in 1997. Dr. Cravatt is a co-founder and scientific advisor of Activx Biosciences, Abide Therapeutics, and Vividion Therapeutics. His honors include a Searle Scholar Award, the Eli Lilly Award in Biological Chemistry, a Cope Scholar Award, the Protein Society Irving Sigal Young Investigator Award, the Tetrahedron Young Investigator Award in Bioorganic and Medicinal Chemistry, the ASBMB Merck Award, and memberships in the National Academy of Sciences and American Academy of Arts and Sciences.

Thomas O. Daniel

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Tom has contributed to innovative healthcare solutions as a practicing physician, scientist, educator, research executive and entrepreneur. Currently Venture Partner at ARCH Venture Partners, he previously led Research & Early Development at Celgene Corporation, where he and colleagues established new corporate collaboration approaches and advanced to approval multiple impactful medicines in oncology and inflammatory diseases. Formerly in senior R&D leadership positions at Immunex, Amgen, and Ambrx, he currently Chairs Locana Bio, and serves as Director at Magenta Therapeutics, Zafgen, VIR Bio, Sana Therapeutics, and Gossamer Bio. He chairs the Board of Overseers of The Scripps Research Institute, advises Vanderbilt University Medical Center, the Parker Institute for Cancer Immunotherapy, is a Trustee of Reed College, and serves as Director for the Lupus Research Alliance. He obtained his undergraduate degree at Southern Methodist University, his medical degree at UT-Southwestern Medical School, trained in Internal Medicine at Massachusetts General Hospital, and was formerly Hakim Professor of Medicine at Vanderbilt.

Richard Heyman

Chairman
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Richard Heyman currently serves as Chairman of the Board and Co-founder of Metacrine Inc., a biotech company developing innovative drugs for patients with metabolic disease.  Previously, he was the co-founder and CEO of Aragon and Seragon Pharmaceuticals; two San Diego biotech companies focused on discovering and developing next generation therapeutics for hormone dependent cancers.  Johnson & Johnson purchased Aragon in 2013 and Genentech/Roche purchased Seragon in 2014.  Following his post-doctoral training at the Salk Institute, Dr. Heyman joined and held various roles at Ligand Pharmaceuticals, including Vice President of Research

Dr. Heyman is also actively involved in ORIC Pharmaceuticals, an oncology based biotech company where he serves as a board member and served as interim CEO from in 2015/2016.  He also serves on the boards of Gritstone Oncology and Yumanity Therapeutics and was a Board member of Receptos Inc. (recently sold to Celgene).  Dr. Heyman serves as Vice Chair on the Board of Trustees of the Salk Institute for Biological Studies, Board Foundation for the AACR and both the Executive Committee and Board of Visitors at the UCSD Moores Cancer Center. Dr. Heyman received a PhD in pharmacology and a BS in chemistry.   He is the author or inventor on more than 120 publications and patents.

Jakob Loven

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Jakob Loven, Ph.D., joined Nextech Invest as Partner in 2017, bringing the passion of a serial entrepreneur. Jakob joined Nextech from Third Rock, where he focused on new company formation in the areas of oncology and emerging technologies. He also served on the firm’s scientific ideation team, overseeing several early-stage projects and leading efforts to transform emerging areas of science into innovative drug discovery companies with unique scientific platforms. While at Third Rock, Jakob launched Relay Therapeutics in Cambridge Massachusetts, which was selected as one of Fiercebiotech’s Fierce 15 in 2017. Prior to Relay, Jakob was a Founding Scientist of Syros Pharmaceuticals (NASDAQ: SYRS), which was founded on his co-discoveries in gene regulation sciences and technologies. Jakob holds a BA in Biomedical Sciences from the Anglia Ruskin University of Cambridge, earned his Ph.D. in Medical Sciences from Karolinska Institutet, and conducted his postdoctoral fellowship at the Whitehead Institute for Biomedical Research. During his appointment at the Whitehead Institute, Jakob pioneered the field of gene regulation research through numerous scientific findings, authoring several high-impact journal articles.

Jakob manages Nextech’s investments in Autolus, A2 Biotherapeutics, Arvinas and Turning Point Therapeutics.

Diego Miralles

CEO
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Diego comes from an extensive background in leading and developing innovative businesses. He was previously President of Adaptive Therapeutics, where he built a therapeutics program leveraging Adaptive immunosequencing platform. He had an extensive career at Johnson & Johnson, which he joined in 2005 as VP of Clinical Development at Tibotec in Belgium where he was involved in the development and approval of PREZISTA® and INTELENCE®, among several other drugs in the portfolio. In 2008, he moved back to the US to head the Janssen Research and Early Development unit in La Jolla, CA.

While at Johnson & Johnson, he founded and launched the JLABS incubator in 2012 for start-up life science entrepreneurs, a model that has been replicated in six locations across North America, and was instrumental in developing and launching Johnson & Johnson’s Innovation center model in 2013. Additionally, he established Janssen Healthcare Innovation in 2011. Through his external networking activities, he contributed significantly to Johnson & Johnson’s growing reputation as an innovative healthcare company.

Prior to Johnson & Johnson, Diego held R&D positions at Trimeris and Triangle Pharmaceuticals and was an Assistant Professor at Duke University Medical Center, where he was a bench scientist and an Infectious Disease physician, with a focus on HIV. He is currently an Adjunct Professor in the Department of Pharmacology at the University of California San Diego. He received his MD degree from the Universidad de Buenos Aires, Argentina. He completed his internal medicine residency at the Mayo Clinic and was a fellow in Infectious Diseases at Cornell University-New York Hospital.

Diego has a strong passion for advancing healthcare innovation on behalf of patients.

Thomas Woiwode

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Thomas Woiwode has been with Versant Ventures since 2002, serving as a Venture Partner since 2011 and a Managing Director since 2014.  Mr. Woiwode has served in a number of operating roles over this time, most recently as the Chief Operating Officer of Okairos, a biopharmaceutical company developing genetic vaccines for major infectious diseases. He led the process that culminated in the sale of Okairos to GlaxoSmithKline for $325M. Prior to his role with Okairos, Mr. Woiwode co-founded EuroVentures, a wholly owned biotech incubator within Versant Ventures, and in this role, served as the founding Chief Business Officer for three biotech companies created within Versant: Flexion (public), Synosia (public, merged with BioTie), and Amira (acquired by Bristol-Myers Squibb for up to $475M). Prior to his role as a Venture Partner, he was an Associate at Versant Ventures and served on the boards of Antipodean, Metabolex and Saegis. Mr Woiwode was a research scientist at XenoPort before joining Versant. He earned his PhD in Organic Chemistry as an NSF Fellow at Stanford University and graduated summa cum laude with a BA in English and received the Departmental Citation for his B.S. in Chemistry from UC Berkeley.

Mr. Woiwode currently serves on the boards of Annapurna, Anokion, Audentes, CRISPR, Gritstone, Kanyos Bio, and Therachon.

Careers

Innovators at work…

We are a dedicated, energetic team committed to transforming the future of medicine.

Offering the best…

Our emerging, collaborative work culture is supported with large company perks, from health insurance to time off, we’ll have you covered.

Expand your horizons…

We’re looking for experienced, like-minded individuals to join us.

Current Job Openings…

Formulation Scientist/Senior Scientist

Don’t See a Fit? Please note: Our team is growing… Check back often for new opportunities!

Investors

Contact

Vividion Therapeutics
5820 Nancy Ridge Drive
San Diego, CA 92121
858.345.4690
information@vividion.com

Media/Investor Contact
Nick Veomett
media@vividion.com
858.257.1535